Diseases referred to as ribosomopathies are those whose ribosomal components are flawed or whose ribosome biogenesis is compromised. Human cancer risk is significantly increased by abnormal ribosomal function. Defects in ribosome production have the ability to activate the p53 pathway, which is a major modulator of many clinical traits of ribosomal disorders. Consequently, it is anticipated that mechanistic research on specific anomalies in ribosome biogenesis may result in new treatment options for these conditions.
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